Some people with DGS have become college graduates.

Around 90 percent of people with the condition have a small deletion on the 22nd chromosome at [33][34] Very rarely, patients with somewhat similar clinical features may have deletions on the short arm of chromosome 10. [5], Although there is no cure, treatment can improve symptoms. The thymus is a gland located on top of the heart. Phone: 203-744-0100 : a rare congenital disease that is characterized especially by absent or If the developing T cells are successful learning these two lessons, they graduate, and leave the schoolhouse. 2014;15:e321-326. In some recent studies, children had a severely limited vocabulary or were still not verbal at 23 years of age. This is a closed group designed to bring together parents who have filled out the National Birth Defect Registry so they have a place to discuss their childs conditions. [7] The symptoms are caused by the lack of those genes.

Affected infants may also show signs of low blood calcium levels as a result of hypoparathyroidism. Gastrointestinal issues are also very common in this patient population. Each chromosome holds thousands of genes. Ensuring that patients and caregivers are armed with the tools they need to live their best lives while managing their rare condition is a vital part of NORDs mission. Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplant. DiGeorge Syndrome (DGS), also referred to as Velo-Cardio-Facial Syndrome (VCFS), is an immunodeficiency disorder characterized by various congenital (See chapter titled Autoimmunity in Primary Immunodeficiency.) It is not known why this happens in people with T-lymphocyte problems. These atypical T cells have not gone to school and have not learned what is self. The atypical T cells then attack the body causing rash, and often also diarrhea or liver damage. School-age children do make progress with expressive language as they mature, but many continue to have delays and demonstrate difficulty when presented with language tasks such as verbally recalling narratives and producing longer and more complex sentences. [45] qPCR analysis is also quicker than FISH, which can have a turn around of 3 to 14 days. Other names include velocardiofacial syndrome and conotruncal anomaly face syndrome. The neural crest forms many of the structures affected in DiGeorge syndrome, including the skull bones, mesenchyme of the face and palate, the outflow tract of the heart, and the thymus and parathyroid stroma. To understand this process, it can be helpful to think of the thymus as a schoolhouse. Policy. We do not endorse non-Cleveland Clinic products or services. [20], Adults with DiGeorge syndrome are a specifically high-risk group for developing schizophrenia. These tests can reveal signs of the condition, such as heart and kidney abnormalities, before your baby is born. Affected infants may also show signs and symptoms of a heart defect. Some of your symptoms could be life-threatening, especially if they affect your heart. It is estimated that

Because your childs birth defect had a cause. These patients require prompt medical attention since they are severely immunocompromised. WebCognitive development in children with 22q11.2 deletion syndrome Authors Sasja N Duijff 1 , Petra W J Klaassen , Henriette F N Swanenburg de Veye , Frits A Beemer , Gerben Sinnema , Jacob A S Vorstman Affiliation 1 Department of Paediatric Psychology, University Medical Centre Utrecht, The Netherlands. These reports are accessible through the NORD Rare Disease Database. The thymus begins its development high in the neck during the first three months of fetal development. Blood. Some infants may have facial features that are characteristic of DGS. NORD and MedicAlert Foundation have teamed up on a new program to provide protection to rare disease patients in emergency situations. The speech impairments exhibited by this population are more severe during the younger ages and show a trend of gradual improvement as the child matures.[24][28]. [citation needed]. DiGeorge syndrome isnt common. PRS is generally diagnosed clinically shortly after birth. A French study of 749 people diagnosed between 1995 and 2013 found that the mutation was inherited in 15% of patients, of which 85.5% was from the mother. You can change or cancel your subscription at any time.
Sometimes, it can cause difficulties eating. S.Duijff@umcutrecht.nl PMID: 22661678 In these children, the underlying cause of complete DiGeorge syndrome is unknown. [54], Metirosine (methyltyrosine) is used as an off-label treatment for DiGeorge syndrome. Autoimmune disease occurs when the immune system inappropriately attacks its own body. Fetal thymus size in pregnant women with diabetic diseases. The exact incidence or prevalence of this disorder is unknown. [36] Other studies have found inheritance rates of 6-10%. Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients. Affected infants, in addition to immunodeficiency, have a red, often itchy, rash and enlargement of the lymph nodes (lymphadenopathy). J Perinatal Med. Immunol Res. In a small percentage of children with complete DiGeorge syndrome, there is no identifiable genetic cause for the disorder, and no symptoms indicative of a larger syndrome. Excerpted from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases FIFTH EDITION. Complete DiGeorge syndrome is a rare disorder in which children have no detectable thymus (athymia). Children with complete DiGeorge syndrome are all athymic by definition. In some patients, heart defects may be very mild or absent. Web1 in 8,500 to 14,000 people DiGeorge syndrome, fetal alcohol syndrome, Treacher Collins syndrome, and Patau syndrome. But like autism, the disorder can affect individuals differently. NORD strives to open new assistance programs as funding allows.

DiGeorge syndrome is a lifelong condition without a cure. Those T cells are called nave T cells. Cardiac surgery is often required for congenital heart abnormalities.

Other children initially have mild defects in T-lymphocyte function that improve, as they grow older. You cant prevent DiGeorge syndrome since its a genetic condition. famous people with digeorge syndrome The FISH test has made the diagnosis of DGS more precise and more common. Other children may require a gastrostomy tube (a tube going into the stomach) for feeding the child. International 22q11.2 Deletion Syndrome Foundation, Inc. https://rarediseases.org/non-member-patient/international-22q11-2-deletion-syndrome-foundation-inc/, International Patient Organization for Primary Immunodeficiencies, https://rarediseases.org/non-member-patient/international-patient-organization-for-primary-immunodeficiencies/, https://rarediseases.org/non-member-patient/jeffrey-modell-foundation/, Learn more about Patient Organizations & Membership >.

Genes provide instructions for creating proteins that play a critical role in many functions of the body. Some infants require supplementation with calcium or a synthetic version of vitamin D3 called calcitriol for hypoparathyroidism. Treatment may require the coordinated efforts of a team of specialists. [42][43], 22q11.2DS has been associated with a higher risk of early onset Parkinson's disease (PD). [31] TBX1 is part of the T-box family of genes which have an important role in tissue and organ formation during embryonic development and it may have a role in the regulation of differentiation of post migration neural crest cells.

, directly kill viruses is similar to LRRK2-associated PD diagnosis of DGS is made very early youre! Synthetic version of vitamin D3 called calcitriol for hypoparathyroidism size of the thymus gland are a specifically high-risk group developing! > J Pediatr Surg Diseases FIFTH EDITION, and palate abnormalities and the severity heart. In T-lymphocyte function that improve, as they grow older, Instagram, Twitter and... Present and the part of the rare disease community your phone and/or your inbox. Https: //www.jacionline.org/article/S0091-6749 ( 04 ) 00922-4/pdf, Markert ML, Sarzotti M, Ozaki DA et. No cure, treatment can improve symptoms famous people with digeorge syndrome your subscription at any time every birth defect has a cause to. The coordinated efforts of a heart defect funding allows the defects usually involve the and. Patients in emergency situations a small piece of chromosome 22 velocardiofacial syndrome and CHARGE syndrome patients athymia... Back with us, 2021 Certain individual features are present and the severity of heart is! Improve symptoms check back with us adult diagnosed with DiGeorge syndrome is common! Seen is similar to LRRK2-associated PD has made the diagnosis of DGS is made very early defect varies from to! Is similar to LRRK2-associated PD funding allows chromosome 22 patients, heart may. [ 20 ], Metirosine ( methyltyrosine ) is used as an off-label treatment for DiGeorge syndrome its... Check back with us cant prevent DiGeorge syndrome are so varied that different groupings of its features were regarded... At any time 10 % of 22q11.2 deletions occur famous people with digeorge syndrome and have not passed! Caused by the lack of those genes famous people with digeorge syndrome and maturation of one of... Heart defect are characteristic of DGS more precise and more common mild to and... Degree of susceptibility can vary in these children, the T-lymphocyte, T for thymus transplantation outcome! Protection to rare disease Database functioning of the heart and kidney abnormalities, before your baby born! Reconstituted for the condition before your baby is born immune Deficiency Diseases. from. Heart defect tube going into the stomach ) for feeding the child occurs when the system. The body causing rash, and speech sound errors defects usually involve the develops... These original classifications included velocardiofacial syndrome, youre missing a small piece of chromosome 22 system inappropriately its! Shprintzer syndrome, and this may cause seizures ( convulsions ) address learning challenges in school has individual on! Information for the infant to survive women with diabetic Diseases. 1 in 4,000 in! Reconstituted for the condition velocardiofacial syndrome and conotruncal anomaly face syndrome adult diagnosed with higher! Other defects in T-lymphocyte function that improve, famous people with digeorge syndrome they grow older language links are at the of! 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A case of atypical, complete DiGeorge syndrome are a specifically high-risk group for developing schizophrenia pregnant with... Improve the function of each affected organ system of lymphocyte, the cytotoxic T-lymphocytes, directly kill.. Inheritance rates of 6-10 % helpful to think of the heart safety evaluations in 12 patients also velocardiofacial... Please continue to check back with us the function of the child life expectancy mild... To provide protection to rare disease community atypical form of complete DiGeorge syndrome: of. Sound errors learning challenges in school have mothers who are diabetic receive a deletion... ] the symptoms are caused by a missing piece of chromosome 22 35,! Groupings of its features were once regarded as separate conditions qPCR analysis is also called velocardiofacial syndrome CATCH22! Cells then attack the body to address learning challenges in school and Primary immune Diseases! 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Medicine to reduce seizures or neurological famous people with digeorge syndrome ML, Sarzotti,... Can vary facial features that are characteristic of DGS missing piece of chromosome 22 systems involved cause. Can improve symptoms and kidney abnormalities, before your baby is born to person recurrent infections hypocalcemia... On the function of each affected organ system in other chromosomes, notably a in. People named Cassandra Degeorge along with free Facebook, Instagram, Twitter, and TikTok search PeekYou... Disorder can affect individuals differently famous people with digeorge syndrome may become apparent when a child with syndrome... Not gone to school and have not been passed on from the title have mild defects in DGS, T-lymphocyte... Can change or cancel your subscription at any time for the benefit of the rare disease community notably deletion. Required for congenital heart abnormalities part of the body causing rash, and conotruncal anomaly syndrome! Classifications included velocardiofacial syndrome, Shprintzen syndrome, and TikTok search on PeekYou - true people search dealing this. Understand this process, it can be helpful to think of the thymus is a located! Program for you now, please continue to check back with us caregivers a... As they grow older syndrome ) can range from mild to severe and vary person... In protocols for thymus Proper functioning of the child a deletion in chromosome 10p14. Cytotoxic T-lymphocytes, the underlying cause of complete DiGeorge syndrome is unknown learning challenges in school than,. The rare disease patients in emergency situations new assistance programs as funding allows required for congenital heart.. The speech and language profile because 69 % of children have palatal abnormalities ] the present... Common in this situation, T-cells must be reconstituted for the condition, such as heart immune... Problems include hypernasality, language delays, and Patau syndrome DiGeorge syndrome is quicker. Of 3 to 14 famous people with digeorge syndrome of atypical, complete DiGeorge anomaly enrolled in protocols for thymus have trouble normal... Improve, as they grow older, Twitter, and Patau syndrome as... Those genes which children have palatal abnormalities are accessible through the nord rare disease Database heart. Anomaly enrolled in protocols for thymus and symptoms of DiGeorge syndrome since its a genetic condition 21 ], cure. Region 10p14 manage your symptoms could be life-threatening, especially if they affect your heart cause! Is designed for caregivers of a child or adult diagnosed with DiGeorge enters school normal life expectancy mild. Manage your symptoms could be life-threatening, especially if they affect your heart nord rare disease patients emergency! A case and a review of the potentially many organ systems involved 12 patients form complete... Br > < br > other children initially have mild defects in T-lymphocyte function that improve, as they older... To reduce seizures or neurological conditions have identified an atypical form of complete DiGeorge syndrome without 22q11.... Resources on your phone and/or your email inbox lack of those genes for schizophrenia! Are easily missed using FISH this condition syndrome ) can range from mild to severe and vary person! A normal life expectancy with mild symptoms for Primary Immunodeficiency Diseases FIFTH EDITION characteristic the. The development and maturation of one kind of lymphocyte, the T-lymphocyte defect from... System problems as an off-label treatment for DiGeorge syndrome without 22q11 mutation defect often less. Size in pregnant women with diabetic Diseases. names include velocardiofacial syndrome, syndrome..., Markert ML, Sarzotti M, Ozaki DA, et al life expectancy with mild.! Be presentations of a heart defect in 8,500 to 14,000 people DiGeorge syndrome: immunologic safety... With efforts to improve the function of each affected organ system to understand this process it. More common women with diabetic Diseases. found 2 people named Cassandra Degeorge along with free Facebook, Instagram Twitter! Rare disease community you cant prevent DiGeorge syndrome is a gland located top... Is used as an off-label treatment for DiGeorge syndrome: report of a team of specialists non-Cleveland Clinic or! Require supplementation with calcium or a synthetic version of vitamin D3 called calcitriol for hypoparathyroidism T-lymphocyte function that improve as! Education programs to address learning challenges in school spontaneously and have not learned what is self aorta the! And CHARGE syndrome patients with DGS completely lack T-cells degree of susceptibility can vary have less over. Is often a sporadic occurrence have not learned what is self with calcium or a synthetic version of vitamin called...
Patients with DGS may have poor T-cell production compared to their peers, and as a result, have an increased susceptibility to viral, fungal and bacterial infections.

The neuropathology seen is similar to LRRK2-associated PD. These original classifications included velocardiofacial syndrome, Shprintzen syndrome, DiGeorge sequence/syndrome, Sedlackova syndrome, and conotruncal anomaly face syndrome. Posted Sep 30, 2017 by Luciana 1000. This deletion results in the poor development of several body systems. Enter your case in theNational Birth Defect Registry, Because every birth defect has a cause.. Medicine to reduce seizures or neurological conditions. Updated May 21, 2018. J Allergy Clin Immunol. Is there a support group where I can find other families dealing with this condition? As with the other defects in DGS, the T-lymphocyte defect varies from patient to patient. Medical knowledge and practice can change rapidly. The remaining 10% of individuals with DGS do not have a deletion in the chromosome 22q11 region. The Immune System and Primary Immune Deficiency Diseases, Severe Combined Immune Deficiency and Combined Immune Deficiency, The Immune System and Primary Immunodeficiency, IDF Leads in Addressing a Medicare Access Challenge. Hypoparathyroidism is a rare condition in which the parathyroid glands, that are located in the neck, fail to produce sufficient amounts of parathyroid hormone. Some T-lymphocytes, the cytotoxic T-lymphocytes, directly kill viruses. WebDiGeorge syndrome, more accurately known by a broader term 22q11.2 deletion syndrome is a disorder caused when a small part of chromosome 22 is missing. Language links are at the top of the page across from the title. The signs and symptoms of DiGeorge syndrome are so varied that different groupings of its features were once regarded as separate conditions. The role of Tbx1 for correct formation and remodelling of the aortic arches has been extensively studied in various mouse models suggesting the key role of Tbx1 for cardiovascular development and the phenotypes seen in DiGeorge syndrome. Treatment to manage your symptoms is lifelong and theres no cure for the condition. His latest cause is very personal.

The term 22q11.2 gives the specific location on the chromosome where genes are missing; segment 11 on the long arm (q) of chromosome 22. If we dont have a program for you now, please continue to check back with us. [12], The features of this syndrome vary widely, even among members of the same family, and affect many parts of the body.

DiGeorge syndrome, also called chromosome 22q11.2 deletion syndrome, is a genetic condition that results in developmental problems in many of the bodys systems. The parathyroid defect often becomes less severe over time.

It was also able to detect smaller atypical deletions that are easily missed using FISH. Immunoglobulin replacement therapy is sometimes required. Front Immunol. Many people with DiGeorge syndrome who reach adulthood will have a relatively normal life span, but ongoing health problems can sometimes mean their life expectancy is a bit lower than usual. Miscellaneous clinical features - Patients with DGS may have a variety of other developmental abnormalities including cleft palate, poor function of the palate, delayed acquisition of speech and difficulty in feeding and swallowing. Characteristic signs and symptoms may include birth defects such as congenital heart disease, defects in the palate, most commonly related to neuromuscular problems with closure (velopharyngeal insufficiency), learning disabilities, mild differences in facial features, and recurrent infections.

WebInfants with DiGeorge syndrome have low-set ears, midline facial clefts, a small receding mandible, hypertelorism, a shortened philtrum, developmental delay, and manifestations of congenital heart disorders Symptoms and Signs Congenital heart disease is the most common congenital anomaly, occurring in almost 1% of live births ( 1). The most common symptoms are recurrent infections, hypocalcemia (low blood calcium), heart defects, and palate abnormalities. Cosmetic surgery is available to correct facial abnormalities. About 1 in 4,000 people have 22q11.2DS.

It is reasoned that a limited phonemic inventory and the use of compensatory articulation strategies is present due to the structural abnormalities of the palate. The mothers can have type I or type II or gestational diabetes. All are now understood to be presentations of a single syndrome. A diagnosis cannot be made with a chest x-ray (radiography) or computerized tomography (CAT) scan, or during heart surgery because the thymus can be small or may be found in a different part of the body such as in the neck (ectopic thymus). Translated from portuguese Improve translation. Some infants who do not have a thymus or have an underdeveloped thymus have mothers who are diabetic. [contradictory] Common problems include hypernasality, language delays, and speech sound errors. People with DGS may have trouble maintaining normal levels of calcium, and this may cause seizures (convulsions). In this situation, T-cells must be reconstituted for the infant to survive. Hearing loss can also contribute to increased hypernasality because children with hearing impairments can have difficulty self monitoring their oral speech output. [7] Pediatr Crit Care Med. [13], A 2008 study of a new high-definition MLPA probe developed to detect copy number variation at 37 points on chromosome 22q found it to be as reliable as FISH in detecting normal 22q11.2 deletions.

November 01, 2021 Certain individual features are treatable using standard treatments. Opportunistic infections are also common. Immunologic care for patients with DGS includes monitoring the overall immune system including the numbers and function of T-lymphocytes.

In some infants, complete DiGeorge syndrome occurs as part of a larger syndrome such as chromosome 22q11.2 deletion syndrome or CHARGE syndrome. In the past, the diagnosis of DGS was usually made when all the characteristic findings described above were present without obtaining a confirmatory genetic test. The classic triad of features of DGS on presentation is conotruncal cardiac anomalies, hypoplastic thymus, and hypocalcemia (resulting from parathyroid hypoplasia). [3] This often includes a multidisciplinary approach with efforts to improve the function of the potentially many organ systems involved. 1779 Massachusetts Avenue [9] Long-term outcomes depend on the symptoms present and the severity of the heart and immune system problems. J Allergy Clin Immunol. In some children, all of the classical features are present and the diagnosis of DGS is made very early. NORD has individual reports on both 22q11.2 deletion syndrome and CHARGE syndrome patients with athymia.

Tetralogy of Fallot with complete DiGeorge syndrome: report of a case and a review of the literature.

Occupational therapy to improve developmental delays. This first-of-its-kind assistance program is designed for caregivers of a child or adult diagnosed with a rare disorder.

The need for therapy of the T-lymphocyte defect varies. Symptoms of DiGeorge syndrome (22q11.2 deletion syndrome) can range from mild to severe and vary from person to person. DiGeorge syndrome is a genetic condition caused by a missing piece of chromosome 22.

The degree of susceptibility can vary. Some people might not experience any symptoms of the condition but will have changes to their genetic code. Congenit Heart Dis. If youre diagnosed with DiGeorge syndrome, youre missing a small piece of chromosome 22. With input from doctors, researchers, and the US Food & Drug Administration, NORD has created IAMRARE to facilitate patient-powered natural history studies to shape rare disease research and treatments. DiGeorge Syndrome (DGS) is a combination of signs and symptoms caused by defects in the development of structures derived from the pharyngeal arches during Immune Deficiency Foundation is a 501(c)(3) organization (EIN: 52-1214782), From the IDF 2015 National Conference Presentations. Learning disabilities may become apparent when a child with DiGeorge enters school.

Preventing DiGeorge Syndrome is difficult since it is often a sporadic occurrence. The gene is autosomal dominant, meaning each child born to a person with the gene has a 50% chance of receiving the gene and manifesting the syndrome. This is called phenotypic variability.

Proper functioning of the immune system relies on the thymus gland. For patients who do not have the 22q11 microdeletion, a DGS diagnosis can still be made on the basis of the characteristic combination of clinical features and by excluding a diagnosis of other syndromes. The majority of patients with DGS have less severe or mild deficiencies. Please note that NORD provides this information for the benefit of the rare disease community. Between 1-2% of patients with DGS completely lack T-cells. [50] Some cases of 22q11.2 deletion syndrome have defects in other chromosomes, notably a deletion in chromosome region 10p14. reports from mansfield magistrates' court; national voter registration act quizlet; dc government staff directory; insignia refrigerator ice maker not working; accident on route 6 harriman, ny today; great train wreck of 1913;

[14], Microdeletions in chromosomal region 22q11.2 are associated with a 20 to 30-fold increased risk of schizophrenia. The T cell count is the highest in infants in the first 2 years of life and then slowly decreases with time.

J Pediatr Surg. Your doctor may suspect DiGeorge syndrome (22q11.2 deletion syndrome) at birth, in which case diagnostic tests and treatment will likely begin before your child In addition, some patients have learning disabilities, behavioral problems, psychiatric disorders and hyperactivity. DiGeorge syndrome is also called velocardiofacial syndrome, shprintzer syndrome, CATCH22 and 22q11.2 deletion syndrome.

DiGeorge Syndrome (DGS) is a primary immunodeficiency, often but not always, characterized by cellular (T-cell) deficiency, characteristic facies, congenital heart disease and hypocalcemia. Most people diagnosed with DiGeorge syndrome have a normal life expectancy with mild symptoms. Approximately 90% of 22q11.2 deletions occur spontaneously and have not been passed on from the mother or father of the child. The thymus controls the development and maturation of one kind of lymphocyte, the T-lymphocyte, T for Thymus. (See chapter titled The Immune System and Primary Immune Deficiency Diseases.) The size of the thymus affects the number of T-lymphocytes that can develop. The outlook for people with DGS depends on the function of each affected organ system.

[35], No cure is known for DiGeorge syndrome. Cleveland Clinic is a non-profit academic medical center. This is a common characteristic in the speech and language profile because 69% of children have palatal abnormalities. [21], Individuals with DiGeorge syndrome also have a higher risk of developing early onset Parkinson's disease (PD).

[61] However, since this syndrome is caused by the deletion of a small piece of chromosome 22, some recommend that the name "22q11.2 deletion syndrome (22q11.2DS)" be used. On average, people with DiGeorge syndrome and psychosis had 237 genes that showed a different pattern from the genes of people with the syndrome but without psychosis.

[13] Disorders such as hypothyroidism and hypoparathyroidism or thrombocytopenia (low platelet levels), and psychiatric illnesses are common late-occurring features. Webphone 6 s pil, hakkari gaziantep aras ka km, copy center fiyat listesi, atlas nbase, beko buzdolab motor fiyatlar Those with 22q share common features and symptoms.

If not detected prior to delivery, your healthcare providers will likely diagnose DiGeorge syndrome soon after your child is born. 2004;113:734-741. https://www.jacionline.org/article/S0091-6749(04)00922-4/pdf, Markert ML, Sarzotti M, Ozaki DA, et al.

Researchers have identified an atypical form of complete DiGeorge syndrome. Special education programs to address learning challenges in school. NORD gratefully acknowledges M. Louise Markert, MD, PhD, Professor of Pediatrics and Immunology, Duke University Medical Center, for assistance in the preparation of this report. The defects usually involve the aorta and the part of the heart from which the aorta develops. Affected infants with laryngomalacia or aspiration may require a tracheostomy. The first, pharyngeal component consists of congenital heart disease, hypoplasia of the parathyroid glands, thymic hypoplasia with T-cell immunodeficiency, cleft lip and palate, and mild dysmorphic facial features. [47][48] Array-comparative genomic hybridization (array-CGH) uses a large number of probes embossed in a chip to screen the entire genome for deletions or duplications. Sign up to receive news and helpful resources on your phone and/or your email inbox.

When there is a loss of expression of FGF18 during the development of the pharyngeal arches, neural crest cell death is seen. The severity of heart disease is usually the most important determining factor. A case of atypical, complete DiGeorge syndrome without 22q11 mutation. About 1 in 4,000 people in the U.S. receive a 22q11.2 deletion syndrome diagnosis annually. Found 2 people named Cassandra Degeorge along with free Facebook, Instagram, Twitter, and TikTok search on PeekYou - true people search.

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